Mass spectrometry imaging and LC/MS reveal decreased cerebellar phosphoinositides in Niemann-Pick type C1-null mice
Koralege C. Pathmasiri, Melissa R. Pergande, Fernando Tobias, Rima Rebiai, Avia Rosenhouse‐Dantsker, Ernesto R. Bongarzone, Stephanie M. Cologna
Abstract
-null mouse model, as observed by Western blot analysis. Our discovery of phosphoinositide lipid biomarkers for NPC1 opens new perspectives on the pathophysiology underlying this fatal neurodegenerative disease.
Topics & Concepts
Mass spectrometryMass spectrometry imagingChemistryCerebellumNeuroscienceChromatographyBiologyLysosomal Storage Disorders ResearchCellular transport and secretionErythrocyte Function and Pathophysiology