Development of the VISAGE enhanced tool and statistical models for epigenetic age estimation in blood, buccal cells and bones
Anna Woźniak, Antonia Heidegger, Danuta Piniewska-Róg, Ewelina Pośpiech, Catarina Xavier, Aleksandra Pisarek, Ewa Kartasińska, Michał Boroń, A. Freire-Aradas, Marta Wojtas, M. de la Puente, Harald Niederstätter, Rafał Płoski, Magdalena Spólnicka, Manfred Kayser, Christopher Phillips, Walther Parson, Wojciech Branicki
Abstract
and predicts age with MAE of 3.4 years. The VISAGE enhanced tool for age estimation in somatic tissues enables reliable collection of DNA methylation data from small amounts of DNA using a sensitive multiplex MPS assay that provides accurate estimation of age in blood, buccal swabs, and bones using the statistical model tailored to each tissue.
Topics & Concepts
Buccal swabDNA methylationEpigeneticsMultiplexBiologyComputational biologyBuccal administrationBioinformaticsGeneticsGeneGene expressionEpigenetics and DNA MethylationCancer-related gene regulation