Targeted exosome coating gene-chem nanocomplex as “nanoscavenger” for clearing α-synuclein and immune activation of Parkinson’s disease
Linying Liu, Yan Li, Huan Peng, Ruiyuan Liu, Weihong Ji, Zhuyan Shi, Jie Shen, Guanghui Ma, Xin Zhang
Abstract
(REXO-C/ANP/S). It is a nanoscavenger for clearing α-synuclein aggregates and reducing their cytotoxicity in Parkinson's disease neurons. The motor behavior of Parkinson's disease mice is substantially improved after REXO-C/ANP/S treatment. In particular, we demonstrate that REXO-C/ANP/S is also a nanoscavenger for clearing immune activation due to its natural immature dendritic cell EXO coating. Our findings show that REXO-C/ANP/S may serve as a platform for neurodegenerative diseases treatment.
Topics & Concepts
Parkinson's diseaseImmune systemDiseaseMicrovesiclesAlpha-synucleinClearingExosomeGeneMedicineBiologyImmunologyGeneticsmicroRNAPathologyEconomicsFinanceNeuroinflammation and Neurodegeneration MechanismsConducting polymers and applicationsParkinson's Disease Mechanisms and Treatments