Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity
Xinyi Xu, Haotian Chen, Zhengxu Ren, Xiaomin Xu, Wei Wu, Haochen Yang, JinJiao Wang, Yumeng Zhang, Qiuping Zhou, Hua Li, Shaoqing Zhang, Haopeng Wang, Chenqi Xu
Topics & Concepts
BiologyImmunological synapseCytotoxicityAntigenChimeric antigen receptorCell biologyImmunologyReceptorVirologyImmune systemT-cell receptorT cellGeneticsIn vitroCAR-T cell therapy researchImmunotherapy and Immune ResponsesImmune Cell Function and Interaction