Oral squamous cell carcinoma outcome in adolescent/young adult: Systematic review and m<scp>eta‐analysis</scp>
Estela Kaminagakura, Rubens Nisie Tango, Danyel Elias da Cruz Pérez, Roberta Ferreti Bonan, Luciana Yamamoto Almeida, Maria Letícia de Almeida Lança, Paulo Rogério Ferreti Bonan, Hélder Domiciano Dantas Martins, Ademar Takahama, Fábio Augusto Ito, Cláudia Malheiros Coutinho‐Camillo, Sílvia Vanessa Lourenço, Taciana Marco Ferraz Caneppele, Andrew G. Sikora, Luiz Paulo Kowalski, Simon Young
Abstract
To perform a systematic review focusing on the prognosis of oral cavity squamous cell carcinoma (OSCC) in young patients (≤40 years old) compared to older (>40 years old). Four databases were used in our search strategy. First, all titles were systematically organized using the Covidence platform online. In the second phase, 118 full texts of potentially eligible studies were analyzed by reviewers independently and in pairs. Twelve studies were considered eligible for data extraction. The relapse was higher in the young than in controls (pooled relative risk (RR) = 1.31; 95% CI [1.10-1.56]). The 5-year disease-free survival (DFS) was worse in young group (pooled hazard ratio (HR) = 0.73; 95% CI [0.63-0.85]) but the 5-year overall survival (OS) estimate was similar between the groups (pooled HR = 0.84; 95% CI [0.70-1.00]). While the 5-year OS was similar between groups, the number of relapses and 5-year DFS were worse in patients with OSCC ≤40 years old.