Akkermansia muciniphila-derived small extracellular vesicles attenuate intestinal ischemia-reperfusion-induced postoperative cognitive dysfunction by suppressing microglia activation via the TLR2/4 signaling
Xiang Gao, Chuantao Lin, Yebin Feng, Yi You, Zhe Jin, Mengyun Li, Yufeng Zhou, Kai Chen
Topics & Concepts
MicrogliaPharmacologyInflammationPostoperative cognitive dysfunctionTLR2Blood–brain barrierMedicineBiologyNeuroscienceTLR4ImmunologyCentral nervous systemCognitionNeuroinflammation and Neurodegeneration MechanismsIntensive Care Unit Cognitive DisordersBarrier Structure and Function Studies