Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents
Debabrata Maity, Sunil Kumar, Ruyof AlHussein, Lothar Gremer, Madeline Howarth, Laura Karpauskaite, Wolfgang Hoyer, Mazin Magzoub, Andrew D. Hamilton
Abstract
Naphthalimide-appended oligopyridylamide peptidomimetic modulate islet amyloid polypeptide amyloidogenesis and disaggregate preformed oligomers and fibrils into non-toxic conformations at substoichiometric concentration.
Topics & Concepts
PeptidomimeticAmyloid (mycology)ChemistryStoichiometryAmyloid βBiochemistryOrganic chemistryMedicineInternal medicinePeptideDiseaseInorganic chemistryAlzheimer's disease research and treatmentsProtein Structure and DynamicsMachine Learning in Bioinformatics