Design, synthesis and biological evaluation of imidazolidine-2,4-dione and 2-thioxothiazolidin-4-one derivatives as lymphoid-specific tyrosine phosphatase inhibitors
Xiao Liang, Huansheng Fu, Peng Xiao, Hao Fang, Xuben Hou
Topics & Concepts
ChemistryProtein tyrosine phosphataseJurkat cellsImidazolidineIC50PhosphataseT-cell receptorBiochemistryStereochemistryTyrosineT cellPharmacologyImmune systemEnzymeIn vitroImmunologyBiologyProtein Tyrosine PhosphatasesGalectins and Cancer BiologyCytokine Signaling Pathways and Interactions