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Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate Dengue from Zika and West Nile viruses

Wioletta Rut, Katarzyna Groborz, Linlin Zhang, Sylwia Modrzycka, Marcin Poręba, Rolf Hilgenfeld, Marcin Drąg

2020Antiviral Research26 citationsDOI

Topics & Concepts

NS3Dengue feverProteasesDengue virusZika virusProteaseFlavivirusVirologyBiologyFlaviviridaeYellow feverVirusComputational biologyBiochemistryViral diseaseEnzymeHepatitis C virusMosquito-borne diseases and controlMalaria Research and ControlStudies on Chitinases and Chitosanases
Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate Dengue from Zika and West Nile viruses | Litcius