Iron‐Catalyzed Radical Activation Mechanism for Denitrogenative Rearrangement Over C(sp<sup>3</sup>)–H Amination
Satyajit Roy, Sandip Das, Hillol Khatua, Subrata Das, Krishna Nand Singh, Buddhadeb Chattopadhyay
Abstract
Abstract An iron‐catalyzed denitrogenative rearrangement of 1,2,3,4‐tetrazole is developed over the competitive C(sp 3 )–H amination. This catalytic rearrangement reaction follows an unprecedented metalloradical activation mechanism. Employing the developed method, a wide number of complex‐N‐heterocyclic product classes have been accessed. The synthetic utility of this radical activation method is showcased with the short synthesis of a bioactive molecule. Collectively, this discovery underlines the progress of radical activation strategy that should find wide application in the perspective of medicinal chemistry, drug discovery and natural product synthesis research.