Skeletal myopathy in CKD: a comparison of adenine-induced nephropathy and 5/6 nephrectomy models in mice
Kyoungrae Kim, Erik Anderson, Trace Thome, Guanyi Lu, Zachary R. Salyers, Tomas A. Cort, Kerri A. O’Malley, Salvatore T. Scali, Terence E. Ryan
Abstract
Numerous preclinical models of chronic kidney disease have been used to evaluate skeletal muscle pathology; however, direct comparisons of popular models are not available. In this study, we compared adenine-induced nephropathy and 5/6 nephrectomy models. Both models produced equivalent levels of muscle atrophy and mitochondrial impairment, but the adenine model exhibited lower mortality rates, higher consistency in uremic toxin levels, and dysregulated phosphate homeostasis compared with the 5/6 nephrectomy model.
Topics & Concepts
Internal medicineEndocrinologyRenal functionNephrectomyKidney diseaseMedicineNephropathyHyperphosphatemiaSkeletal muscleSarcopeniaChemistryKidneyDiabetes mellitusDialysis and Renal Disease ManagementBipolar Disorder and TreatmentParathyroid Disorders and Treatments