Computational prediction of interaction and pharmacokinetics profile study for polyamino-polycarboxylic ligands on binding with human serum albumin
Nidhi Chadha, Dushyant Singh, Marilyn Daisy Milton, Gauri Mishra, Joseph C. Daniel, Anil K. Mishra, Anjani K. Tiwari
Abstract
Human serum albumin (HSA) is one of the most abundant plasma proteins available in blood and responsible for transport of fatty acids, drugs and metabolites at its binding sites which are very important for the assessment of pharmacokinetics profile of the polyamino-polycarboxylic ligands.
Topics & Concepts
ChemistryHuman serum albuminPharmacokineticsAlbuminSerum albuminPlasma protein bindingBlood proteinsHuman plasmaBinding siteBiochemistryChromatographyPharmacologyMedicineProtein Interaction Studies and Fluorescence AnalysisProtein purification and stabilityDrug Transport and Resistance Mechanisms