Identification of a KPC Variant Conferring Resistance to Ceftazidime-Avibactam from ST11 Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Strains
Yuchen Wu, Xuemei Yang, Congcong Liu, Yanyan Zhang, Yan Chu Cheung, Edward Wai‐Chi Chan, Sheng Chen, Rong Zhang
Abstract
Ceftazidime-avibactam (CZA) is a novel β-lactam/β-lactamase inhibitor combination with activity against serine β-lactamases, including the Ambler class A enzyme KPC. However, during recent years, there have been increasing reports of emergence of new KPC variants that could confer resistance to CZA.
Topics & Concepts
Ceftazidime/avibactamKlebsiella pneumoniaeAvibactamCeftazidimeMicrobiologyBiologyEscherichia coliEnterobacteriaceaeBeta-Lactamase InhibitorsGeneGeneticsBacteriaAntibioticsPseudomonas aeruginosaAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyPneumonia and Respiratory Infections