Synthesis of tryptophan-containing 2,5-diketopiperazines <i>via</i> sequential C–H activation: total syntheses of tryprostatin A, maremycins A and B
Xue‐Song Yin, Weiyi Qi, Bing‐Feng Shi
Abstract
Indole 2,5-diketopiperazines (DKPs) are an important type of metabolic cyclic dipeptides containing a tryptophan (Trp) unit possessing a range of interesting biological activities.
Topics & Concepts
DiketopiperazinesTryptophanTotal synthesisChemistryStereochemistryAmino acidBiochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsMicrobial Natural Products and Biosynthesis