Cobalt‐Catalyzed, 2‐Aminopyridine‐N‐Oxide‐Directed C(sp<sup>2</sup>)−H Bond Functionalization with Maleimides: Facile Access to Isoindolone Spirosuccinimides
Raj N. Patel, Dharmik M. Patel, Nileshkumar B. Rathod, Dinesh Gopichand Thakur, Sachinkumar D. Patel, Srinu Tothadi, Subhash Chandra Ghosh
Abstract
Abstract A cobalt‐catalyzed, N,O‐bidentate directing group‐assisted C−H bond functionalization of benzamides with maleimides was developed for the facile access to isoindolone spirosuccinimides in good to excellent yields. This C−H bond activation and spirocyclization employing pyridine N‐oxide as directing group provided very good substrate scope and tolerated various functional groups. Furthermore, the mechanistic investigation revealed that the C−H bond activation is the rate‐determining step of this reaction.
Topics & Concepts
ChemistryCatalysisSurface modificationSubstrate (aquarium)PyridineCobaltDenticityFunctional groupCombinatorial chemistryOxideMedicinal chemistryPolymer chemistryOrganic chemistryCrystal structurePhysical chemistryGeologyOceanographyPolymerCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSynthesis and pharmacology of benzodiazepine derivatives