CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2
Panyang Shen, Yute Yang, Gang Liu, Weijie Chen, Junxing Chen, Qingxin Wang, Hongliang Gao, Shunwu Fan, Shuying Shen, Xing Zhao
Abstract
Our study revealed an important role of CircCDK14/miR-125a-5p/Smad2 axis in OA progression and provided a potential molecular therapeutic strategy for the treatment of OA.
Topics & Concepts
Western blotOsteoarthritisCatabolismGene knockdownExtracellular matrixCartilageApoptosisCancer researchSignal transductionAnabolismIn vivoCell biologyChemistryBiologyMedicinePathologyBiochemistryGeneMetabolismAnatomyAlternative medicineBiotechnologyCircular RNAs in diseasesOsteoarthritis Treatment and Mechanisms