TET1s deficiency exacerbates oscillatory shear flow-induced atherosclerosis
Kai Qu, Caihong Wang, Lu Huang, Xian Qin, Kun Zhang, Yuan Zhong, Qingfeng Ma, Wenhua Yan, Tianhan Li, Peng Qin, Yi Wang, Hans Gregersen, Chaojun Tang, Juhui Qiu, Guixue Wang
Abstract
These data demonstrate the unexpected discovery that laminar shear stress induces TET1s expression to protect the vascular endothelial barrier by increasing CX40 expression in ECs and that TET1s overexpression may be the core step for OSS-induced atherosclerosis therapy.
Topics & Concepts
Gene knockdownInflammationDownregulation and upregulationCancer researchPathologyOccludinBiologyCell biologyChemistryMedicineTight junctionImmunologyGeneBiochemistryKruppel-like factors researchGenetic Associations and EpidemiologyEpigenetics and DNA Methylation