Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors
Aladdin M. Srour, Nesreen S. Ahmed, Somaia S. Abd El‐Karim, Manal M. Anwar, Salwa M. El‐Hallouty
Topics & Concepts
ErlotinibChemistryEGFR inhibitorsThiazoleEpidermal growth factor receptorIC50Quantitative structure–activity relationshipPotencyPharmacologyDocking (animal)MTT assayStereochemistryBenzimidazoleCell cycleIn vitroApoptosisBiochemistryReceptorBiologyNursingMedicineOrganic chemistrySynthesis and biological activityComputational Drug Discovery MethodsClick Chemistry and Applications