Amphiphilic phenylalanine derivatives that temporally generate reactive oxygen species from water in the presence of Au(<scp>iii</scp>) ions
Somnath D. Bhagat, Aasheesh Srivastava
Abstract
O) or organic solvents as the reaction medium, while an increase in the pH of the aqueous medium intensified both these processes. We exploited the temporal ROS generation using the mixture of 1 and Au(iii) ions towards anticancer therapy by enhancing the intracellular ROS levels. It is expected that this effort can be expanded into a viable anticancer therapy in the near future by modulating the amount and the rate of ROS-generation through judicious choice of the peptidic ligands and metal ions.
Topics & Concepts
PhenylalanineAmphiphileChemistryReactive oxygen speciesOxygenIonCombinatorial chemistryBiochemistryOrganic chemistryAmino acidCopolymerPolymerMolecular Sensors and Ion DetectionMetal complexes synthesis and propertiesPorphyrin and Phthalocyanine Chemistry