Forskolin-driven conversion of human somatic cells into induced neurons through regulation of the cAMP-CREB1-JNK signaling
Guodong Wang, Dandan Zhang, Liangshan Qin, Quanhui Liu, Wenkui Tang, Mingxing Liu, Fan Xu, Fen Tang, Leping Cheng, Huiming Mo, Xiang Yuan, Zhiqiang Wang, Ben Huang
Abstract
Overall, our studies identify a safer and efficient single-small-molecule-driven reprogramming approach for induced neuron generation and reveal a novel regulatory mechanism of neuronal cell fate acquisition.
Topics & Concepts
ReprogrammingForskolinCell biologyCREB1BiologyGlutamatergicNeuronIBMXOptogeneticsInterneuronNeuroscienceTranscription factorChemistryCellCREBGlutamate receptorInhibitory postsynaptic potentialStimulationReceptorBiochemistryGenePluripotent Stem Cells ResearchNeuroscience and Neural EngineeringCRISPR and Genetic Engineering