Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer
Jiaxin Chen, Yizheng Wu, Xin Luo, Dongai Jin, Wei Zhou, Zhenyu Ju, Di Wang, Qing Meng, Huijuan Wang, Xiaotian Fu, Jianbin Xu, Zhangfa Song
Abstract
Our findings indicate that circRHOBTB3 exerts suppressive effects on CRC aggressiveness through the HuR/PTBP1 axis.
Topics & Concepts
MetastasisCancer researchColorectal cancerRNAMessenger RNABiologyLong non-coding RNARNA-binding proteinCircular RNADownregulation and upregulationCancerImmunoprecipitationCell growthMolecular biologyCell cultureGeneGeneticsCircular RNAs in diseasesRNA modifications and cancerCancer-related molecular mechanisms research