A reduction-responsive drug delivery with improved stability: disulfide crosslinked micelles of small amiphiphilic molecules
Man Li, Longbing Ling, Qing Xia, Xinsong Li
Abstract
anti-tumor activity in a 4T1 xenograft tumor model. In summary, the di-LA-PC crosslinked micelle platform possesses excellent stability, high loading capacity and reduction-responsive release profile, which may have applications in the delivery of PTX and other anti-cancer drugs.
Topics & Concepts
MicelleDisulfide bondChemistryDrug deliveryReduction (mathematics)Combinatorial chemistryMoleculeDrugChemical engineeringOrganic chemistryPharmacologyAqueous solutionMedicineBiochemistryGeometryMathematicsEngineeringNanoparticle-Based Drug DeliverySurfactants and Colloidal SystemsDendrimers and Hyperbranched Polymers