Mapping of mTOR drug targets: Featured platforms for anti-cancer drug discovery
Raef Shams, Yoshihiro Ito, Hideyuki Miyatake
Topics & Concepts
PI3K/AKT/mTOR pathwaymTORC2mTORC1RPTORMechanistic target of rapamycinDrug discoveryCell growthBiologyCancer cellAllosteric regulationDiscovery and development of mTOR inhibitorsSirolimusCell biologyCancer researchCancerChemistrySignal transductionBiochemistryReceptorGeneticsPI3K/AKT/mTOR signaling in cancerEnzyme function and inhibitionProtein Kinase Regulation and GTPase Signaling