Rhodium(<scp>iii</scp>)-catalyzed regioselective C2-alkenylation of indoles with CF<sub>3</sub>-imidoyl sulfoxonium ylides to give multi-functionalized enamines using a migratable directing group
Zuguang Yang, Jianhua Tang, Chen Li, Zhengkai Chen, Xiao‐Feng Wu
Abstract
-imidoyl sulfoxonium ylides (TFISYs) as alkenylating agents for the first time. A wide array of indolyl- and trifluoromethyl-decorated enamine derivatives have been assembled in moderate to good yields.
Topics & Concepts
RegioselectivityRhodiumChemistryEnamineCatalysisTrifluoromethylCombinatorial chemistryMedicinal chemistryOrganic chemistryAlkylCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsFluorine in Organic Chemistry