Systemic Disease Associations with Disorders of Gut–Brain Interaction and Gastrointestinal Transit: A Review
Rohitha Moudgal, Andrew W. Schultz, Eric D. Shah
Abstract
Abstract: Functional gastrointestinal disorders (FGID) are now classified within the Rome IV framework as disorders of gut–brain interaction (DGBI). Disorders of gastrointestinal transit (as defined by abnormalities on contemporary gastrointestinal motility testing) frequently are associated with symptoms that are also characteristic of DGBIs. In this narrative review, we outline a non-inclusive set of systemic diseases or risk factors that have been classically associated with DGBIs and disorders of gastrointestinal transit; these include diabetes mellitus, paraneoplastic syndromes, surgery, Parkinson’s disease, systemic sclerosis, endocrinopathies, polypharmacy, and post-infectious syndromes. Keywords: motility, neurogastroenterology, gastroenterology, mechanism A Letter to the Editor has been published for this article. A Response to Letter has been published for this article.