Rapid Enrichment and Sensitive Detection of Trace Chloronicotinyl Insecticide Residues in Honey Samples Based on Magnetic Covalent Organic Framework
Xiaoli Wang, Xiaoli Wang, Hong-Shuai Geng, Lu Liu, Ling-Xi Zhao, Na Li, Hai‐Long Jiang, Xia Wang, Xia Wang, Xiangfeng Chen, Ru‐Song Zhao
Abstract
Establishing an effective method for insecticide residue analysis is critical for food safety control. This study reported a convenient and sensitive approach for extracting and analyzing trace chloronicotinyl insecticides (CNIs) in honey samples. A magnetic covalent organic framework (Fe 3 O 4 @PyTTA-DHPA-COFs) was synthesized and employed as an adsorbent in magnetic solid phase extraction (m-SPE). The Fe 3 O 4 @PyTTA-DHPA-COFs exhibited efficient and rapid adsorption (5 min) for CNIs. The m-SPE-HPLC-MS/MS method for trace analysis of CNIs in honey samples was established with good linearity (0.5–200 ng g –1 ) and a low limit of quantitation (0.05–0.95 ng g –1 ). CNI residues (0.93–4.38 ng g –1 ) were detected in real honey samples, much lower than the maximum residue levels (MRLs) of CNIs in honey. The recoveries of CNIs in spiked honey samples were 72.1–106% with RSD < 9.5%. The successful application demonstrates the potential of this method in trace analysis of CNIs residues.