Angiosarcomas: histology, immunohistochemistry and molecular insights with implications for differential diagnosis.
Isidro Machado, Francisco Giner, Javier Lavernia, Julia Cruz, Víctor Traves, Celia Requena, Beatriz Llombart, José Antonio López-Guerrero, Antonio Llombart-Bosch
Abstract
Angiosarcomas (AS) represent a heterogenous group of tumors with variable clinical presentation. AS share an important morphologic and immunohistochemical overlap with other sarcomas, hence the differential diagnosis is challenging, especially in poorly-differentiated tumors. Although molecular studies provide significant clues, especially in the differential diagnosis with other vascular neoplasms, a thorough hematoxylin and eosin analysis remains an essential tool in AS diagnosis. In this review, we discuss pathological and molecular insights with emphasis on implications for differential diagnosis in cutaneous, breast, soft tissue and visceral AS.