Organocatalytic atroposelective synthesis of axially chiral <i>N</i>,<i>N</i>′-pyrrolylindoles <i>via de novo</i> indole formation
Cong-Shuai Wang, Qi Xiong, Hui Xu, Haoran Yang, Yanfeng Dang, Xiu‐Qin Dong, Chun‐Jiang Wang
Abstract
The first organocatalytic atroposelective synthesis of chiral N,N ′-pyrrolylindoles based on CPA-catalyzed asymmetric 5- endo-dig cyclization of well-designed o -alkynylanilines bearing pyrrolyl unit was established via de novo indole formation.
Topics & Concepts
Indole testChemistryAxial symmetryStereochemistryCombinatorial chemistryPhysicsQuantum mechanicsAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chirality