Myosin heavy chain-derived peptide of<i>Gadus morhua</i>promotes proliferation and differentiation in osteoblasts and bone formation and maintains bone homeostasis in ovariectomized mice
Meilian Yang, Shuzhen Cheng, Wuchao Ma, Di Wu, Hesham R. El‐Seedi, Zhenyu Wang, Ming Du
Abstract
). Moreover, P-GM-1 promotes bone formation, maintains bone homeostasis, and prevents osteoporosis in ovariectomized mice by regulating the BMP/Smad signaling pathway. This study confirmed the potential of GMP in the regulation of bone mineral density and provided a certain theoretical basis for the development of anti-osteoporosis active factors from GMP.
Topics & Concepts
ChemistryOsteoblastOvariectomized ratBone remodelingWnt signaling pathwayCell biologyGadusInternal medicineSMADBone growthEndocrinologyBone mineralOsteoporosisSignal transductionBiochemistryBiologyIn vitroHormoneFish <Actinopterygii>FisheryMedicineProtein Hydrolysis and Bioactive PeptidesBone and Dental Protein StudiesBone Metabolism and Diseases