Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury
Bin He, Wei Chen, Jingsong Zeng, Wusong Tong, Ping Zheng
Abstract
experiments validated that NKILA-containing EVs promoted brain recovery following TBI. Collectively, astrocyte-derived EVs carrying NKILA was found to alleviate neuronal injury in TBI by competitively binding to miR-195 and upregulating NLRX1.
Topics & Concepts
AstrocyteTraumatic brain injuryCell biologyExtracellular vesiclesExtracellularChemistryLong non-coding RNARNANeuroscienceBiophysicsBiologyMedicineBiochemistryGeneCentral nervous systemPsychiatryCancer-related molecular mechanisms researchExtracellular vesicles in diseaseTraumatic Brain Injury and Neurovascular Disturbances