CuCl<sub>2</sub>‐Catalyzed <i>α</i>‐Chloroketonation of Aromatic Alkenes via Visible‐Light‐Induced LMCT
Xing‐Xian He, Huan‐Huan Chang, Ying‐Xue Zhao, Xiangjie Li, Sheng‐An Liu, Zhong‐Lin Zang, Cheng‐He Zhou, Gui‐Xin Cai
Abstract
Here we report a copper-catalyzed protocol for the synthesis of α-chloroketones from aromatic alkenes including electron-deficient olefins under visible-light irradiation. Preliminary mechanistic studies show that the peroxo Cu(II) species is the key intermediate and hydroperoxyl (HOO⋅) and chlorine (Cl⋅) radicals can be generated by ligand-to-metal charge transfer (LMCT).
Topics & Concepts
HydroperoxylPhotochemistryCatalysisRadicalVisible spectrumChemistryCopperChlorineElectron transferMetalIrradiationMaterials scienceOrganic chemistryPhysicsNuclear physicsOptoelectronicsCatalytic C–H Functionalization MethodsVanadium and Halogenation ChemistryRadical Photochemical Reactions