Gout and <scp>NLRP3</scp> Inflammasome Biology
Raewyn C. Poulsen, Nicola Dalbeth
Abstract
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilization, and self-resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal-induced inflammation is reviewed in detail. Treatment strategies for gout are outlined in the context of the mechanisms of NLRP3 inflammasome-mediated acute inflammation.
Topics & Concepts
InflammasomeGoutPyrin domainCell biologyComputational biologyBiologyChemistryImmunologyInflammationBiochemistryInflammasome and immune disordersGout, Hyperuricemia, Uric AcidHeme Oxygenase-1 and Carbon Monoxide