Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model
Takuro Okamura, Masahide Hamaguchi, Ryo Bamba, Hanako Nakajima, Yuta Yoshimura, Tomonori Kimura, Kensuke Nishida, Yoshitaka Hashimoto, Takuya Fukuda, Takafumi Senmaru, Michiaki Fukui
2020American Journal of Physiology-Gastrointestinal and Liver Physiology31 citationsDOIOpen Access PDF
Abstract
The progression of nonalcoholic fatty liver disease (NAFLD) is associated with testosterone deficiency. NAFLD patients generally do not respond to treatment with testosterone alone. In animal studies, treatment with testosterone and estrogen reduced the ratios of ILC2:CD45 and ILC3:CD45 and increased M2 macrophages in liver. Our study suggests, based on our immunological data, that a combination of estrogen and testosterone may be clinically relevant for the treatment of NAFLD in patients with male menopause.
Topics & Concepts
Testosterone (patch)Nonalcoholic fatty liver diseaseInternal medicineEstrogenEndocrinologyMedicineImmune systemMenopauseFatty liverDiseaseImmunologyLiver Disease Diagnosis and TreatmentImmune Cell Function and InteractionAdipokines, Inflammation, and Metabolic Diseases