Targeting Lymph Node Niches Enhances Type 1 Immune Responses to Immunization
Jeffrey Lian, Aleksandra J. Ozga, Caroline L. Sokol, Andrew D. Luster
Abstract
T cells are advantageously positioned to encounter arriving IL-12-producing inflammatory dendritic cells (DCs). These data suggest that formulations delivering antigen to the LN IFR create an inflammatory niche that can improve vaccine efficacy.
Topics & Concepts
ImmunizationImmunologyAntigenImmune systemBiologyAntigen-presenting cellT cellT-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Response and Inflammation