A red-emitting thiophene-modified BODIPY probe for fluorescence lifetime-based polarity imaging of lipid droplets in living cells
Rokas Žvirblis, Karolina Maleckaitė, Jelena Dodonova‐Vaitkūnienė, Džiugas Jurgutis, Rugilė Žilėnaite, Vitalijus Karabanovas, Sigitas Tumkevičius, Aurimas Vyšniauskas
Abstract
TP2 was suitable for sensing polarity in lipid droplets of live MCF-7 human breast cancer cells. We demonstrated that different chemotherapeutics affected lipid droplet polarity differently: cisplatin had no effect on lipid droplet polarity, whereas paclitaxel, depending on its concentration, either decreased or increased lipid droplet polarity.
Topics & Concepts
BODIPYFluorescencePolarity (international relations)ThiopheneLipid dropletMaterials sciencePhotochemistryFluorescence-lifetime imaging microscopyBiophysicsChemistryOrganic chemistryOpticsBiochemistryBiologyCellPhysicsLipid metabolism and biosynthesisPhotosynthetic Processes and MechanismsMass Spectrometry Techniques and Applications