Rigidifying a <i>De Novo</i> Enzyme Increases Activity and Induces a Negative Activation Heat Capacity
Sarah A. Hindson, H. Adrian Bunzel, Bettina Frank, Dimitri A. Svistunenko, Christopher Williams, Marc W. van der Kamp, Adrian J. Mulholland, Christopher R. Pudney, J. L. Ross Anderson
Abstract
protein catalysts in particular, this can provide more enzyme-like catalysts without further rational engineering, computational redesign, or directed evolution.
Topics & Concepts
ChemistryEnzymeHorseradish peroxidaseEnzyme catalysisMolecular dynamicsBiocatalysisProtein engineeringActive siteCatalysisProtein structureEnzyme assayStereochemistryComputational chemistryThermodynamicsBiochemistryPhysicsReaction mechanismProtein Structure and DynamicsMicrobial Metabolic Engineering and BioproductionMetabolomics and Mass Spectrometry Studies