Gut microbiota–bile acid axis mediated the beneficial associations between dietary lignans and hyperuricemia: a prospective study
Lai‐Bao Zhuo, Yingdi Yang, Congmei Xiao, Fanqin Li, Lishan Lin, Yue Xi, Yuanqing Fu, Ju‐Sheng Zheng, Yu‐Ming Chen
Abstract
: We found that dietary lignans were inversely associated with hyperuricemia incidence, and the gut microbiota-bile acid axis might mediate this association. Our findings provide new perspectives on precise therapeutic targets and underlying mechanisms for conditions associated with elevated uric acid.
Topics & Concepts
Gut floraHyperuricemiaBile acidProspective cohort studyFarnesoid X receptorMedicineChemistryBiologyInternal medicineBiochemistryUric acidTranscription factorGeneNuclear receptorGout, Hyperuricemia, Uric AcidLiver Disease Diagnosis and TreatmentAlcohol Consumption and Health Effects