PDX: Moving Beyond Drug Screening to Versatile Models for Research Discovery
Gail P. Risbridger, Mitchell G. Lawrence, Renea A. Taylor
Abstract
Patient-derived xenografts (PDXs) are tools of the trade for many researchers from all disciplines and medical specialties. Most endocrinologists, and especially those working in oncology, commonly use PDXs for preclinical drug testing and development, and over the last decade large collections of PDXs have emerged across all tumor streams. In this review, we examine how the field has evolved to include PDXs as versatile resources for research discoveries, providing evidence for guidelines and changes in clinical practice.
Topics & Concepts
MedicineDrug discoveryClinical PracticeDrug developmentDrugPrecision oncologyPrecision medicineData scienceBioinformaticsPathologyBiologyComputer sciencePharmacologyFamily medicineCancer Genomics and DiagnosticsCancer Cells and Metastasis3D Printing in Biomedical Research