Synthesis, characterization, in silico, and in vitro biological screening of coordination compounds with 1,2,4-triazine based biocompatible ligands and selected 3d-metal ions
Rugmini Ammal P, Anupama R. Prasad, Abraham Joseph
Abstract
antimicrobial activities, drug-likeness, bioactivity score prediction by Molinspiration software. Molecular docking analysis of selected compounds on α-amylase and VEGFR-2 kinase were carried out for confirming the experimental observations.
Topics & Concepts
ChemistryLigand (biochemistry)Octahedral molecular geometryDenticityTriazineNuclear chemistryMTT assayMetalThermogravimetric analysisMetal ions in aqueous solutionProton NMRStereochemistryIn vitroOrganic chemistryBiochemistryReceptorSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activitySynthesis of Tetrazole Derivatives