Synthesis of Cyclopropanes via 1,3-Migration of Acyloxy Groups Triggered by Formation of α-Imino Rhodium Carbenes
Ze‐Feng Xu, Jincheng Liu, Xin Chang, Tao Chen, Huaping Xu, Shengguo Duan, Chuan‐Ying Li
Abstract
A novel and highly efficient synthetic approach to cyclopropanes was realized via 1,3-migration of acyloxy groups triggered by α-imino rhodium carbenes. Excellent chemoselectivity ensured broad compatibility of common functional groups. Merits such as readily available substrates, mild reaction conditions, and time-saving processes qualified this transformation as an attractive alternative strategy to synthesize multifunctionalized cyclopropanes. Primary investigations and discussion on the mechanism are presented.
Topics & Concepts
ChemistryRhodiumChemoselectivityCombinatorial chemistryCatalysisCompatibility (geochemistry)StereochemistryOrganic chemistryChemical engineeringEngineeringCyclopropane Reaction MechanismsCatalytic Alkyne ReactionsCatalytic C–H Functionalization Methods