Manganese-Catalyzed C(α)-Alkylation of Oxindoles with Secondary Alcohols via Borrowing Hydrogen
Jagannath Rana, Palaniyappan Nagarasu, Murugan Subaramanian, Akash Mondal, Vedichi Madhu, Ekambaram Balaraman
Abstract
A general and efficient C(α)-alkylation of oxindoles with unactivated secondary alcohols as alkylating agents catalyzed by a newly developed NNN-Mn(II) complex is reported. Mechanistic studies illustrate that the importance of the NH moiety in the complex and M–L cooperation play very important roles during the catalytic transformation.
Topics & Concepts
ChemistryAlkylationCatalysisMoietyManganeseHydrogenOrganic chemistryCombinatorial chemistryMedicinal chemistryAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsCarbon dioxide utilization in catalysis