Block catiomer with flexible cationic segment enhances complexation with siRNA and the delivery performance in vitro
Wenqian Yang, Takuya Miyazaki, Pengwen Chen, Taehun Hong, Mitsuru Naito, Yuji Miyahara, Akira Matsumoto, Kazunori Kataoka, Kanjiro Miyata, Horacio Cabral
Abstract
experiments, PEG-PGBA uPICs promoted effective intracellular delivery of siRNA and efficient gene knockdown. Our results indicate the significance of polycation flexibility on assembling PIC structures with siRNA, and its potential for developing innovative delivery systems.
Topics & Concepts
PEG ratioSmall interfering RNAEthylene glycolGene knockdownRNA interferenceBiophysicsGene silencingIn vitroChemistryMicelleIn vivoTransfectionRNACombinatorial chemistryBiochemistryBiologyAqueous solutionOrganic chemistryApoptosisGeneEconomicsFinanceBiotechnologyRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesDendrimers and Hyperbranched Polymers