Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay
Chunlong Ma, M. Sacco, Zilei Xia, George Lambrinidis, Julia A. Townsend, Yanmei Hu, Xiangzhi Meng, Tommy Szeto, Mandy Ba, Xiujun Zhang, Maura V. Gongora, Fushun Zhang, Michael T. Marty, Yan Xiang, Antonios Kolocouris, Yu Chen, Jun Wang
Abstract
inhibitors in the BSL-2 setting.
Topics & Concepts
PapainProteaseHigh-throughput screeningChemistryEnzymeSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Drug discoveryBiochemistryComputational biologyBiologyCoronavirus disease 2019 (COVID-19)MedicinePathologyDiseaseInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchViral Infections and Immunology ResearchComputational Drug Discovery Methods