Dual-functional antitumor conjugates improving the anti-metastasis effect of combretastatin A4 by targeting tubulin polymerization and matrix metalloproteinases
Limin Yang, Xin Ma, Kerong Guo, Jian Li, Chong Zhang, Liqiang Wu
Topics & Concepts
ChemistryConjugateApoptosisTubulinCell cycle checkpointMatrix metalloproteinaseMMP2CombretastatinReactive oxygen speciesCell cycleMicrotubuleOxidative stressCell growthCancer researchMMP9PharmacologyStereochemistryCell biologyBiochemistryDownregulation and upregulationBiologyGeneMathematical analysisMathematicsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathwaysProtease and Inhibitor Mechanisms