Intestinal inflammation alters the antigen-specific immune response to a skin commensal
Geil R. Merana, Laura R. Dwyer, Miqdad O. Dhariwala, Antonin Weckel, Jeanmarie R. Gonzalez, Joy N. Okoro, Jarish N. Cohen, Courtney Tamaki, Jungmin Han, Preston Tasoff, Yasmin Palacios-Calderon, Connie Ha, Susan V. Lynch, Julia A. Segre, Heidi H. Kong, Michael G. Kattah, Averil Ma, Tiffany C. Scharschmidt
Abstract
mice implicate interleukin (IL)-1 in mediating the altered commensal-specific response. These findings provide mechanistic insight into observed connections between inflammatory skin and intestinal diseases.
Topics & Concepts
ImmunologyImmune systemInflammationColitisBiologyDermatology and Skin DiseasesImmune Response and InflammationIL-33, ST2, and ILC Pathways