Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity
Hawley Kunz, Corey R. Hart, Kevin J. Gries, Mojtaba Parvizi, MARCELLO C. LAURENTI, Chiara Dalla Man, Natalie Moore, Xiaoyan Zhang, Zachary Ryan, Eric C. Polley, Michael D. Jensen, Adrian Vella, Ian R. Lanza
Abstract
Adipose inflammation is proposed to be at the nexus of the systemic inflammation and metabolic derangements associated with obesity. The present study provides evidence to support adipose inflammation as a central feature of the pathophysiology of obesity. Adipose inflammation is associated with systemic and peripheral metabolic derangements, including increased systemic inflammation, reduced insulin sensitivity, and reduced skeletal muscle mitochondrial respiration.
Topics & Concepts
InflammationInsulin resistanceSystemic inflammationAdipose tissueMacrophageObesityMedicineImmunologyBiologyInternal medicineIn vitroBiochemistryAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity