Human colonic catabolism of dietary flavan-3-ol bioactives
Giuseppe Di Pede, Pedro Mena, Letizia Bresciani, Tahani Mazyad Almutairi, Daniele Del Rio, Michael N. Clifford, Alan Crozier
Abstract
Understanding the fate of ingested polyphenols is crucial in elucidating the molecular mechanisms underlying the beneficial effects of a fruit and vegetable-based diet. This review focuses on the colon microbiota-mediated transformation of the flavan-3-ols and the structurally related procyanidins found in dietary plant foods and beverages, plus the flavan-3-ol-derived theaflavins of black tea, and the post-absorption phase II metabolism of the gut microbiota catabolites. Despite significant advances in the last decade major analytical challenges remain. Strategies to address them are presented.
Topics & Concepts
FlavanPolyphenolCatabolismFood scienceChemistryProanthocyanidinMetabolismNutrigenomicsBiochemistryBiologyAntioxidantStereochemistryGeneTea Polyphenols and EffectsPhytochemicals and Antioxidant ActivitiesFermentation and Sensory Analysis