Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4
Xue Liu, Huichun Liang, Huan Fang, Xiao‐Jun Ji, Chuanyu Yang, Zhongmei Zhou, Jing Feng, Ceshi Chen
Abstract
<p indent="0mm">Angiopoietin-1 (ANG1) is a pro-angiogenic regulator that contributes to the progression of solid tumors by stimulating the proliferation, migration and tube formation of vascular endothelial cells, as well as the renewal and stability of blood vessels. However, the functions and mechanisms of ANG1 in triple-negative breast cancer (TNBC) are unclear. The clinical sample database shows that a higher level of ANG1 in TNBC is associated with poor prognosis compared to non-TNBC. In addition, knockdown of <italic>ANG1</italic> inhibits TNBC cell proliferation and induces cell cycle G1 phase arrest and apoptosis. Overexpression of ANG1 promotes tumor growth in nude mice. Mechanistically, ANG1 promotes TNBC by upregulating carboxypeptidase A4 (CPA4) expression. Overall, the ANG1-CPA4 axis can be a therapeutic target for TNBC.