Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells
Kevin Wang, Paulina Coutifaris, David Brocks, Guanning Wang, Tarek Azar, Sabrina Solis, Ajeya Nandi, Shaneaka Anderson, Nicholas Han, Sasikanth Manne, Evgeny Kiner, Chirag Sachar, M.W. Lucas, Sangeeth M. George, Patrick Yan, Melanie Wain Kier, Amy Iarrobino Laughlin, Shawn Kothari, Josephine R. Giles, Divij Mathew, Reem Ghinnagow, Cécile Alanio, Ahron Flowers, Wei Xu, Daniel J. Tenney, Xiaowei Xu, Ravi K. Amaravadi, Giorgos C. Karakousis, Lynn M. Schuchter, Marcus Buggert, Derek A. Oldridge, Andy J. Minn, Christian U. Blank, Jeffrey S. Weber, Tara C. Mitchell, Michael D. Farwell, Ramin S. Herati, Alexander C. Huang
Topics & Concepts
Cytotoxic T cellProgenitor cellImmunologyCD8ProgenitorBiologyClonal deletionCancer researchCell biologyImmune systemT cellStem cellGeneticsIn vitroT-cell receptorCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesImmune Cell Function and Interaction