VPS34 regulates dynamin to determine the endocytosis of mitochondria-targeted zinc oxide nanoparticles in human osteosarcoma cells
Xiaoyu Pan, Guanping He, Bao Hai, Yu Liu, Lei Bian, Yong Lei, Hanwen Zhang, Chenlong Yang, Chuanchao Du, Tianli Mao, Yunlong Ma, Fei Jia, Xinyu Dou, Shuheng Zhai, Xiaoguang Liu
Abstract
ZnO NPs enter into osteosarcoma cells <italic>via</italic> VPS34/dynamin 2 pathway and accumulated in mitochondria, initiating mitophagy and subsequent apoptosis.
Topics & Concepts
MitophagyEndocytosisDynaminOsteosarcomaMitochondrionApoptosisCell biologyDNM1LNanoparticleMaterials scienceCancer researchBiologyAutophagyNanotechnologyBiochemistryCellMitochondrial fissionNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisExtracellular vesicles in disease